Peroxisome proliferation in response to xenobiotics.

نویسندگان

  • J W DePierre
  • A K Sohlenius
  • Y Cai
  • A M Eriksson
  • K Andersson
  • C Sundberg
چکیده

Mantle, T. J., Mannervik, B. and Hayes, J. D., eds.), pp. 2 1 1-22 1, CRC Press, Boca Raton, FL Andersson, C., Mosialou, E., Weinander, R., Hebert, H. and Morgenstern, R. (1993) in Structure and Function of Glutathione Transferases (Tew, K. D., Pickett, C. B.. Mantle, T. J., Mannervik, B. and Hayes, J. D., eds.), pp. 109-1 16, CRC Press, Boca Raton, FL Nicholson, D. W (1993) in Structure and Function of Gluthatione Transferases (Tew, K. D., Pickett, C. B., Mantle, T. J., Mannervik, B. and Hayes, J. D., eds.), pp. 47-62, CRC Press, Boca Raton, FL Mannervik, B., A h , P.. Guthenberg, C., Jensson, H.. Tahir, M. K., Warholm, M. and Jornvall, H. (1985) Proc. Natl. Acad. Sci. USA. 82, 7202-7206 6 Meyer. D. J., Coles, B., Pemble, S. E., Gilmore, K. S., Fraser, G. M. and Ketterer, B. (1991) Biochem. J. 274, 409-4 14 7 Matsumura, F. (1994) Biochem. Pharmacol. 48.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Peroxisome proliferation and hepatocarcinogenesis.

Peroxisome proliferators constitute a novel class of non-mutagenic hepatocarcinogens, all of which induce a similar pleiotropic response consisting of hepatomegaly, proliferation of peroxisomes in the liver parenchyma] cells and the induction of several hepatic enzymes, particularly those of the peroxisomal fatty acid /3oxidation system (1—3). Presently several structurally dissimilar hypolipid...

متن کامل

Xenobiotic-Induced Hepatocyte Proliferation Associated with Constitutive Active/Androstane Receptor (CAR) or Peroxisome Proliferator-Activated Receptor α (PPARα) Is Enhanced by Pregnane X Receptor (PXR) Activation in Mice

Xenobiotic-responsive nuclear receptors pregnane X receptor (PXR), constitutive active/androstane receptor (CAR) and peroxisome proliferator-activated receptor α (PPARα) play pivotal roles in the metabolic functions of the liver such as xenobiotics detoxification and energy metabolism. While CAR or PPARα activation induces hepatocyte proliferation and hepatocarcinogenesis in rodent models, it r...

متن کامل

Cellular adaptation to xenobiotics: Interplay between xenosensors, reactive oxygen species and FOXO transcription factors

Cells adapt to an exposure to xenobiotics by upregulating the biosynthesis of proteins involved in xenobiotic metabolism. This is achieved largely via activation of cellular xenosensors that modulate gene expression. Biotransformation of xenobiotics frequently comes with the generation of reactive oxygen species (ROS). ROS, in turn, are known modulators of signal transduction processes. FOXO (f...

متن کامل

The Pollutant Diethylhexyl Phthalate Regulates Hepatic Energy Metabolism via Species-Specific PPARα-Dependent Mechanisms

BACKGROUND The modulation of energetic homeostasis by pollutants has recently emerged as a potential contributor to the onset of metabolic disorders. Diethylhexyl phthalate (DEHP) is a widely used industrial plasticizer to which humans are widely exposed. Phthalates can activate the three peroxisome proliferator-activated receptor (PPAR) isotypes on cellular models and induce peroxisome prolife...

متن کامل

Hepatic enzyme induction: histopathology.

Hepatic enzyme induction is generally an adaptive response associated with increases in liver weight, induction of gene expression, and morphological changes in hepatocytes. The additive growth and functional demands that initiated the response to hepatic enzyme induction cover a wide range of stimuli including pregnancy and lactation, hormonal fluctuations, dietary constituents, infections ass...

متن کامل

Peroxisomes and oxidative stress.

The discovery of the colocalization of catalase with H2O2-generating oxidases in peroxisomes was the first indication of their involvement in the metabolism of oxygen metabolites. In past decades it has been revealed that peroxisomes participate not only in the generation of reactive oxygen species (ROS) with grave consequences for cell fate such as malignant degeneration but also in cell rescu...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Biochemical Society transactions

دوره 23 2  شماره 

صفحات  -

تاریخ انتشار 1995